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This is a Experimental Study study.

October 3, 2025Clinical ChemistryOpen Access

B-197 First Liquid Chromatography-Tandem Mass Spectrometry Method for Detecting Glial Fibrillary Acidic Protein in Cerebrospinal Fluid

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The LC-MS/MS method achieved a linear detection range from 0.5 ng/mL to 500.0 ng/mL, indicating efficacy.
Analytical performance metrics include a recovery rate between 103.6% to 111.6% and total imprecision of 6.4%-7.9%, confirming method reliability.
Method comparison analysis showed good correlational results (r = 0.824–0.826) with existing immunoassay techniques, highlighting its competitive effectiveness.
Standardization of CSF GFAP measurements is essential to advance diagnostic capabilities in neurodegenerative diseases.

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Implication

This research develops a reliable LC-MS/MS method for measuring GFAP in cerebrospinal fluid, suggesting improvements for neurodegenerative disease diagnostics.

Cite This Study

Yutong Zou (2025) studied this question.

synapsesocial.com/papers/68e040e5a99c246f578b2f23 https://doi.org/10.1093/clinchem/hvaf086.587

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Implication

This research develops a reliable LC-MS/MS method for measuring GFAP in cerebrospinal fluid, suggesting improvements for neurodegenerative disease diagnostics.

B-197 First Liquid Chromatography-Tandem Mass Spectrometry Method for Detecting Glial Fibrillary Acidic Protein in Cerebrospinal Fluid

Key Points

Discussion

Implication

Cite This Study

B-197 First Liquid Chromatography-Tandem Mass Spectrometry Method for Detecting Glial Fibrillary Acidic Protein in Cerebrospinal Fluid

Key Points

Discussion

Implication

Cite This Study

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