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This is a Quantitative Study study (also classified as: Experimental Study).

October 3, 2025Clinical ChemistryOpen Access

B-104 Detection of Blood-Based GFAP Using a Novel Single-Molecule Counting Technology

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The assay achieved a limit of detection of 0.47 pg/mL, demonstrating its high analytical sensitivity for GFAP.
A perfect correlation coefficient of 1.00 was observed when comparing the novel assay to the established Lumipulse® G GFAP method.
Blood samples from Alzheimer's donors showed significantly higher GFAP levels compared to healthy donors, confirming the assay’s clinical relevance.
This sensitive GFAP immunoassay requires very small sample volumes, facilitating further research into neurological disorders.

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Novel GFAP immunoassay shows excellent analytical sensitivity in blood samples, indicating potential in neurological disorders.

Kawada et al. (2025) studied this question.

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