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September 10, 2025Frontiers in NeurologyOpen Access

Glial fibrillary acidic protein in cerebrospinal fluid in humans is sensitive to various pre-analytical conditions: possible explanation and solution

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GFAP concentrations can vary significantly based on pre-analytical conditions, leading to unreliable results.
Samples collected in microtubes remained stable for up to 3 weeks at controlled temperatures, improving GFAP reliability.
Storage temperatures and avoidance of exposure to air crucially affect GFAP levels in cerebrospinal fluid samples.
The study involved measuring GFAP concentrations using sandwich ELISA in samples collected from 167 patients.

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This analysis reveals GFAP variability in cerebrospinal fluid across sample volumes, implying careful handling is crucial.

Evertsson et al. (2025) studied this question.

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