Key result
High-intensity interval training decreased the expression of FAS, ACC, and SREBP-1c compared with diabetic controls (p=0.004, p=0.032, p=0.043) and partially increased miR-122 expression.
Why the study?
Does high-intensity interval training improve NAFLD features via miR-122 induction in high-fat high-fructose diet-induced diabetic rats?
Does high-intensity interval training improve NAFLD features via miR-122 induction in high-fat high-fructose diet-induced diabetic rats?
p-value: p = .004, p = .032, p = .043
High-intensity interval training improves NAFLD features in diabetic rats by modulating hepatic gene expression, showing greater efficacy than continuous endurance training.
HIIT effects on lipogenic genes in diabetic rats are hypothesis-generating; human trials needed before clinical consideration.
Background: Exercise intervention is strongly recommended to manage metabolic diseases. In this study, we investigate, whether HIIT and CET can induce hepatic miR-122 expression, NAFLD rats with diabetes.Methods: 40 Wistar rats divided into 2 groups, non-diabetic (NDC) and diabetic .Type 2 diabetes was induced by high-fat high-fructose diet (HFHFD). Then diabetic rats were subdivided into three groups: diabetic control (HFHFD + DC), CET (HFHFD + CET), and HIIT (HFHFD + HIIT). After eight weeks of exercise on a rodent treadmill, we measured miR-122 and its target genes expression in the liver of rats.Results: HIIT decreased the expression of FAS, ACC, SREBP-1c compared with HFHFD + DC (p = .004, p = .032, p = .043, respectively), and could partially increase miR-122 expression as compared with HFHFD + DC (26.8%, p = .68).Conclusions: Exercise training could be a non-pharmacological intervention for improvement of NAFLD of diabetic rats by induction of miR-122. HIIT had a greater effect on NAFLD amelioration than CET.
No takes yet. Share an insight, caveat, or question.
Kalaki-Jouybari et al. (2018) studied NAFLD with diabetes (n=40). High-intensity interval training (HIIT) vs. Diabetic control was evaluated on Expression of FAS, ACC, and SREBP-1c (p=p = .004, p = .032, p = .043). High-intensity interval training decreased the expression of FAS, ACC, and SREBP-1c compared with diabetic controls (p=0.004, p=0.032, p=0.043) and partially increased miR-122 expression.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: