Key result
High-intensity interval training (HIIT) effectively decreased miR-195 expression and increased left ventricular ejection fraction and fractional shortening in diabetic rats compared with continuous endurance training.
Why the study?
Does high-intensity interval training improve myocardial function and reduce miR-195 expression in a rat model of diet-induced diabetic cardiomyopathy compared to continuous endurance training?
Does high-intensity interval training improve myocardial function and reduce miR-195 expression in a rat model of diet-induced diabetic cardiomyopathy compared to continuous endurance training?
In a rat model of diabetic cardiomyopathy, high-intensity interval training was more effective than continuous endurance training at improving myocardial function and reducing miR-195 expression.
Answers are grounded in this paper and cite their sources.
HIIT may benefit diabetic rat cardiomyopathy models; leaves open translation to humans and any clinical role.
Aims: Regarding the fact that up-regulation of miR-195 in diabetic hearts has a potential role in diabetic cardiomyopathy, the present study investigated whether continuous endurance training (CET) and high-intensity interval training (HIIT) reduces miR-195 expression and which exercise is effective in this regard.Methods: Diabetes was induced by high-fat high-fructose diet (HFHFD). Then, the rats were sub-divided into three categories; sedentary (HFHFD + SED), continuous endurance training (HFHFD + CET), and high-intensity interval training group (HFHFD + HIIT). After eight weeks of running, expression of miR-195 and myocardial function were evaluated.Results: HIIT effectively decreases the expression of miR-195 and increases the expression of Sirt1 and BCL-2 in diabetic rats compared with CET. Our results showed that HIIT compared with CET increases left ventricular ejection fraction (LVEF%) and fractional shortening (FS%).Conclusions: Our results indicated that exercise, especially HIIT is an appropriate strategy for reducing miR-195 and improving myocardial function in diabetic rats compared with CET.
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Khakdan et al. (2018) studied Diabetic cardiomyopathy. High-intensity interval training (HIIT) vs. Continuous endurance training (CET) and sedentary control was evaluated on Expression of miR-195 and myocardial function (LVEF% and FS%). High-intensity interval training (HIIT) effectively decreased miR-195 expression and increased left ventricular ejection fraction and fractional shortening in diabetic rats compared with continuous endurance training.
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