Fixed Eruption in Deeply Pigmented Subjects: Clinical Observations on 350 Patients

Ever since Brocq (1894) directed attention to certain drug- induced eruptions that he called " fixed," in the sense that they were subject to recurrent exacerbation on each subsequent administration of the inducing drug, interest in the subject has increased. Among the many and varied syndromes provoked by new drugs and food additives (Sternberg and Bierman, 1963), fixed eruptions are becoming increasingly common (Welsh, 1961; Welsh and Ede, 1961).