Key result
Nonambulatory status (HR 4.11), serum albumin <2.5 g/dL, and ejection fraction <50% were significant risk factors for 2-year mortality after revascularization for critical limb ischemia.
Why the study?
What are the prognostic factors for two-year mortality after revascularization in patients with critical limb ischemia?
Cohort (n=142)
What are the prognostic factors for two-year mortality after revascularization in patients with critical limb ischemia?
Nonambulatory status, low serum albumin, and reduced ejection fraction are significant predictors of two-year mortality following revascularization for critical limb ischemia.
Answers are grounded in this paper and cite their sources.
Supports risk stratification after CLI revascularization; hypothesis-generating and should not yet change practice.
Purposes The aim of this study was to evaluate the risk factors for the two-year survival after revascularization of critical limb ischemia. Methods Between 2008 and 2012, 142 patients underwent revascularization. A retrospective analysis was performed to measure the risk factor. Results A total 85 patients underwent surgical revascularization, 31 patients underwent endovascular therapy while 26 patients underwent hybrid therapy. By multivariate analysis, the following variables were considered to be risk factors: ejection fraction <50 % (HR, 3.14; 95% CI, 1.22-7.95; P = 0.02), serum albumin level <2.5 g/dL (HR, 3.45; 95% CI, 1.01-11.7; P = 0.04) and nonambulatory status (HR, 4.11; 95% CI, 1.79-9.70; P < 0.01). The two-year survival rate of the patients with no risk factors was 85.5%, while the patients with at least one risk factor had an unfavorable prognosis (one; 56.7%, two; 45.4%). Conclusions The nonambulatory status, serum albumin level <2.5 g/dL and ejection fraction <50% were the risk factors for the two-year mortality after revascularization in critical limb ischemia patients. These risk factors may be useful for the treatment strategy of critical limb ischemia patients.
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Morisaki et al. (2016) conducted a cohort in critical limb ischemia (n=142). Risk factors (ejection fraction <50%, serum albumin <2.5 g/dL, nonambulatory status) vs. No risk factors was evaluated on two-year survival (HR 4.11, 95% CI 1.79-9.70, p=< 0.01). Nonambulatory status (HR 4.11), serum albumin <2.5 g/dL, and ejection fraction <50% were significant risk factors for 2-year mortality after revascularization for critical limb ischemia.
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