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New dideoxynucleosides where the nucleobase is lin-benzoadenine is reported. The key target compound, (S,S)-isodideoxybenzoadenosine, is stable with respect to hydrolytic cleavage of the glycosyl bond and it is a poor substrate for adenosine deaminase. Its monophosphate is not a substrate for AMP deaminase.
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Zhang et al. (1997) studied this question.
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