Key result
Ethylenimine inactivated foot-and-mouth disease virus at substantially faster rates than N-acetylethylenimine while producing an equally potent immunogen.
Ethylenimine demonstrates nearly optimal characteristics as an inactivant for FMDV vaccine preparation, offering faster linear inactivation rates compared to AEI while maintaining immunogenic potency.
Ethylenimine may enable faster FMDV vaccine production; animal data leave open translation to livestock use.
Foot-and-mouth disease virus (FMDV) was inactivated by ethylenimine (EI) at three concentrations and two temperatures. Comparison of inactivation kinetics and the antigenic and immunogenic potency of EI and N-acetylethylenimine (AEI)-inactivated FMDV indicates that EI has nearly optimal characteristics as an inactivant for FMDV vaccine preparation. Although AEI-inactivated FMDV has proved to be a potent specific immunogen, an equivalent percentage of EI inactivated FMDV at substantially faster rates and produced an equally potent immunogen. In addition, EI inactivated FMDV at rates that were essentially linear throughout the loss of nearly all measurable infectivity.
No takes yet. Share an insight, caveat, or question.
H. R. Cunliffe (1973) studied Foot-and-mouth disease virus (FMDV). Ethylenimine (EI) vs. N-acetylethylenimine (AEI) was evaluated on Inactivation kinetics and antigenic/immunogenic potency. Ethylenimine inactivated foot-and-mouth disease virus at substantially faster rates than N-acetylethylenimine while producing an equally potent immunogen.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: