Acetylethyleneimine is a more effective and reliable inactivating agent than formalin for the production of foot-and-mouth disease vaccines, yielding a safe and potent product.
Answers are grounded in this paper and cite their sources.
AEI may enable safer FMD vaccine production than formalin; leaves open translation to commercial or regulatory use.
Suspensions of FMD virus treated with 0·05% formalin at 26° C. for periods up to 144 hr. remained infective for cattle, although the infectivity could not be detected in the presence of aluminium hydroxide. Infectivity was detected in similar virus suspensions which had been treated with 0·05% AEI at 37° C. for 8 hr. but not in suspensions treated for 12 hr. Vaccines prepared from these suspensions were antigenically potent and serum neutralization tests demonstrated the development and regression of serum antibody. The AEI vaccines were at least as potent as the corresponding formalin vaccines.
No takes yet. Share an insight, caveat, or question.
Brown et al. (1963) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: