Key result
Disopyramide phosphate successfully reverted ventricular tachycardia to sinus rhythm and prevented recurrent attacks in a single patient without adverse hemodynamic effects.
Why the study?
Does disopyramide phosphate revert ventricular tachycardia and improve hemodynamics in a patient unresponsive to conventional antiarrhythmic treatment?
Case Report (n=1)
Does disopyramide phosphate revert ventricular tachycardia and improve hemodynamics in a patient unresponsive to conventional antiarrhythmic treatment?
Intravenous followed by oral disopyramide successfully reverted and prevented recurrent ventricular tachycardia without adverse hemodynamic effects in a refractory patient.
May support use in refractory VT; leaves open confirmation in controlled trials.
Administration of disopyramide phosphate (DE) i.v. in two doses, 30 min apart, to a patient with ventricular tachycardia was accompanied by no, or only slight, changes in systemic arterial pressure (SAP), cardiac output (Q), stroke work (SW), and pulmonary artery diastolic pressure (PADP). Heart rate fell from 123 to 103/min. Following reversion to sinus rhythm, which occurred 60 min after the second dose of DE at a serum concentration greater than 4.3 mug/ml, Q ans SW showed significant increases above their control values. PADP fell from 20 to 6 mmHg whereas the mean SAP remained largely unchanged. There seemed to be no adverse effects of drug administration. In this patient, recurrent attacks of ventricular tachycardia not responding to conventional antiarrhythmic treatment could be prevented by oral DE in a dose of 800 mg/day.
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Hulting et al. (1976) conducted a case report in Ventricular tachycardia (n=1). Disopyramide phosphate was evaluated on Reversion to sinus rhythm and hemodynamic changes. Disopyramide phosphate successfully reverted ventricular tachycardia to sinus rhythm and prevented recurrent attacks in a single patient without adverse hemodynamic effects.
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