Key result
Prophylactic intravenous dexamethasone reduced the overall incidence of vomiting after elective tonsillectomy from 72% to 40% (P < 0.001).
Why the study?
Does prophylactic IV dexamethasone reduce vomiting in healthy children undergoing elective tonsillectomy?
Population
133 healthy children aged 2-12 yr undergoing elective tonsillectomy
Comparison
Dexamethasone 150 micro g/kg up to a maximum… vs Placebo administered IV before surgery
Design
RCT, randomized, stratified, blocked, double-blind, placebo-controlled
Follow-up
postdischarge
Authors
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Supports prophylactic dexamethasone in pediatric tonsillectomy; confirms efficacy for postoperative vomiting prevention.
RCT (n=133)
double-blind
stratified, blocked
Does prophylactic IV dexamethasone reduce vomiting in healthy children undergoing elective tonsillectomy?
Absolute Event Rate: 40% vs 72%
p-value: p=<0.001
Prophylactic IV dexamethasone significantly reduces the incidence of postoperative vomiting in children undergoing elective tonsillectomy.
Splinter et al. (1996) conducted an RCT in elective tonsillectomy (n=133). Dexamethasone vs. Placebo was evaluated on overall incidence of vomiting (p=<0.001). Prophylactic intravenous dexamethasone reduced the overall incidence of vomiting after elective tonsillectomy from 72% to 40% (P < 0.001).
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