Replication of FTO Gene associated with lean mass in a Meta-Analysis of Genome-Wide Association Studies

Figures

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  Figure 1. QQ plot. Logarithmic quantile–quantile (QQ) plot of individual SNP-based association for fat-adjusted LMI in the discovery sample.

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  Figure 2. Manhattan plot of discovery GWAS samples.

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  Figure 3. LD plot. Association signals of the 29 significant SNPs of the FTO gene. The Haploview block map for the 29 SNPs, showing pairwise LD in r2, was constructed for Caucasian (CEU) using the 1000 Genomes Project.

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  Figure 4. Forest plot of SNPs with combined p-value less than 1 × 10−11. Regression coefficient (beta) and its 95% confidence interval (CI) are presented in untransformed estimates from individual studies. “Total” refers to the combined meta-analysis.

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  Figure 5. Regional plot of FTO generated using Locus Zoom.

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  Figure 6. (a) Box plot of eQTL rs7201850. (b) Box plot of eQTL rs8044769 Box plot of eQTL variant results (p = 1 × 10−5): rs7201850-muscle skeletal, rs8044769-muscle skeletal. These variants showed significant eQTL in their minor allele.

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  Figure 7. Interaction network for FTO. Proteins in the interaction network were represented with nodes, while the interaction between any two proteins therein was represented with an edge. Line color indicates the type of interaction evidence including known interactions, predicted interactions and other. These interactions contain direct (physical) and indirect (functional) interactions, derived from numerous sources such as experimental repositories, computational prediction methods.