Key result
Advanced NYHA functional class (III/IV) was associated with a lower risk of ventricular arrhythmia (HR 0.52; 95% CI 0.33-0.91; P=0.04) and an increased risk of HF or death in ICD recipients.
Why the study?
Does advanced HF functional class affect the risk of heart failure, death, or ventricular arrhythmia in patients receiving ICD or CRT-D for primary prevention?
Cohort (n=913)
Yes
Does advanced HF functional class affect the risk of heart failure, death, or ventricular arrhythmia in patients receiving ICD or CRT-D for primary prevention?
Hazard Ratio: 0.52 (95% CI 0.33–0.91)
p-value: p=0.04
In patients receiving device therapy for primary prevention, advanced NYHA class is associated with a higher risk of HF or death in ICD recipients but not in CRT-D recipients, while the risk of ventricular arrhythmia is lower in advanced NYHA class regardless of device type.
No takes yet. Share an insight, caveat, or question.
Advanced NYHA class signals lower VA yet higher HF/death risk in ICD recipients; hypothesis-generating and should not yet change device selection.
Suleiman et al. (2015) conducted a cohort in Heart failure (n=913). Advanced NYHA functional class (III/IV) vs. NYHA functional class I/II was evaluated on Ventricular arrhythmia (VA) (HR 0.52, 95% CI 0.33-0.91, p=0.04). Advanced NYHA functional class (III/IV) was associated with a lower risk of ventricular arrhythmia (HR 0.52; 95% CI 0.33-0.91; P=0.04) and an increased risk of HF or death in ICD recipients.
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