Key result
A high sodium, high chloride diet significantly increased blood pressure in angiotensin II-treated rats compared to a low sodium, low chloride diet (p<0.05).
Why the study?
Does selective dietary sodium and/or chloride loading affect blood pressure and renal blood flow in a rat model of angiotensin II-induced hypertension?
Does selective dietary sodium and/or chloride loading affect blood pressure and renal blood flow in a rat model of angiotensin II-induced hypertension?
Both sodium and chloride are necessary to produce the maximum increase of blood pressure in angiotensin II-induced hypertension, and AII enhances the decreased renal blood flow induced by dietary chloride.
The effect of selective dietary sodium and (or) chloride loading on blood pressure and renal blood flow (RBF) in the rat angiotensin II (AII) model of hypertension was determined. AII (200 ng/min) or saline was infused intraperitoneally. Diets were provided with either high or low concentrations of sodium, chloride or both ions for 22 days. The blood pressure of saline-treated animals was not increased by the high sodium chloride diet. Animals on a high sodium, high chloride diet had a significantly greater increase of blood pressure at 8, 15, 18, and 22 days of AII infusion compared with AII-treated animals on a low sodium, low chloride diet (p less than 0.05). Selective dietary loading of either high sodium or chloride in AII-treated rats produced no greater elevation of blood pressure than AII with the low sodium, low chloride diet. Selective high dietary chloride was associated with a lower RBF in AII- and vehicle-treated rats compared with low dietary chloride. The chloride effect on RBF was greater in AII-treated animals. In conclusion, both sodium chloride are necessary to produce the maximum increase of blood pressure in AII animals. AII enhances the decreased RBF induced by dietary chloride.
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Passmore et al. (1991) studied Angiotensin II-induced hypertension. Selective dietary sodium and (or) chloride loading vs. Low sodium, low chloride diet was evaluated on Blood pressure and renal blood flow (p=<0.05). A high sodium, high chloride diet significantly increased blood pressure in angiotensin II-treated rats compared to a low sodium, low chloride diet (p<0.05).
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