Key result
Intraoperative magnesium administration does not reduce postoperative atrial fibrillation after cardiac surgery.
Why the study?
Does intraoperative magnesium administration reduce postoperative atrial fibrillation after cardiac surgery?
Does intraoperative magnesium administration reduce postoperative atrial fibrillation after cardiac surgery?
Intraoperative magnesium administration does not appear to reduce the incidence of postoperative atrial fibrillation following cardiac surgery.
No change to POAF prophylaxis indicated; Level 5 data leaves open need for RCTs.
(Abstracted from Anesth Analg, 121:861–867, 2015) Postoperative atrial fibrillation (POAF), defined in this study as supraventricular tachycardia with absence of distinct p-waves and irregular R-R intervals, has a peak incidence on postoperative day 2 and is associated with increased cardiovascular, renal, and cerebral morbidity and mortality. It is thought magnesium (Mg) may have beneficial effects on preventing POAF because hypomagnesemia may promote atrial fibrillation (AF) through prolongation of the atrial effective refractory period, reduction of myocardial excitability, and decreased rates of diastolic depolarization of sinoatrial pacemaker cells.
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Klinger et al. (2016) studied Postoperative atrial fibrillation after cardiac surgery. Intraoperative magnesium administration was evaluated on Postoperative atrial fibrillation (POAF). Intraoperative magnesium administration does not reduce postoperative atrial fibrillation after cardiac surgery.
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