Key result
Microvascular fibrin deposition early after cardiac transplantation is associated with prothrombogenic changes and the subsequent development of transplant coronary artery disease.
This review highlights the predictive value of early microvascular fibrin deposition for the development of transplant coronary artery disease and discusses potential preventive therapeutic approaches.
Suggests early fibrin deposition as a risk marker post-transplant; leaves open whether antithrombotic strategies alter coronary disease progression.
The development of transplant coronary artery disease (CAD) is directly associated with outcome in cardiac transplantation. The relationship between microvascular fibrin deposition early after transplantation and subsequent development of transplant CAD is discussed in this article. In this article the presence of microvascular fibrin and its association with other prothrombogenic changes within the cardiac microvasculature, such as loss of vascular antithrombin, depletion of arteriolar tissue plasminogen activator, and presence of arterial and arteriolar endothelium activation, as well as changes in circulation associated with prothrombogenic changes that have predictive value for subsequent transplant outcome are presented and discussed. Novel therapeutic approaches that may prevent the development of transplant CAD and consequently affect outcome are considered.
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Carlos A. Labarrere (1999) conducted a review in Cardiac transplantation and transplant coronary artery disease. Microvascular fibrin deposition was evaluated on Development of transplant coronary artery disease (CAD) and transplant outcome. Microvascular fibrin deposition early after cardiac transplantation is associated with prothrombogenic changes and the subsequent development of transplant coronary artery disease.
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