Key result
Vaginal delivery was associated with significantly higher maternal serum adiponectin levels compared to cesarean section (P < 0.001).
Why the study?
Cesarean section rates are rising worldwide and adiponectin, which has anti-inflammatory and anti-atherogenic effects, may change in response to inflammatory conditions like surgical intervention.
Does mode of delivery affect maternal and umbilical cord blood adiponectin levels in healthy pregnant women?
Observational (n=75)
No
Does mode of delivery affect maternal and umbilical cord blood adiponectin levels in healthy pregnant women?
p-value: p=< 0.001
Maternal adiponectin concentration is significantly higher following vaginal delivery compared to cesarean section, possibly due to increased release during labor.
Vaginal delivery may elevate maternal adiponectin; leaves open causal effects on labor physiology or neonatal outcomes.
BACKGROUND: The rate of cesarean section is increasing worldwide. Adiponectin is a hormone related to anti-inflammatory and anti-atherogenic effects; and it's concentrations may change in response to inflammatory situations including surgical intervention. The aim of the current study was to investigate serum adiponectin levels in maternal and umbilical cord blood according to different modes of delivery and their relationship with anthropometric measurements and fetal sex. METHODS: The study population initially comprised 90 healthy pregnant women referred to the teaching hospital. Eventually, 40 participants in the vaginal delivery group and 35 subjects in the cesarean delivery group were recruited in to the study. Umbilical cord blood and maternal serum samples were analyzed according to the standard protocol from the manufacturer. The collected data were analyzed using SPSS-16 software. P-value < 0.05 was considered as the significance level for all tests. RESULTS: Our results indicated a significant association between maternal adiponectin and the mode of delivery, with adiponectin levels significantly higher in vaginal delivery compared to cesarean section (P < 0.001). However, no difference was found in umbilical cord blood adiponectin between the two groups (P = 0.51). A significant positive correlation was found between maternal serum adiponectin in the first day after birth and umbilical cord blood adiponectin in the vaginal delivery group (P = 0.007). Nevertheless, this correlation was not statistically significant in the cesarean delivery group (P = 0.62). There was also no significant correlation between fetal sex and anthropometric measurements with maternal adiponectin (P = 0.44) and umbilical cord blood adiponectin (P = 0.86). CONCLUSIONS: The result of the current study revealed that maternal adiponectin concentration was significantly higher in vaginal delivery compared to cesarean section, which might be due to the increased levels of maternal adiponectin release during labor.
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Daryasari et al. (2019) conducted an observational in Healthy pregnancy (n=75). Vaginal delivery vs. Cesarean delivery was evaluated on Maternal serum adiponectin levels (p=< 0.001). Vaginal delivery was associated with significantly higher maternal serum adiponectin levels compared to cesarean section (P < 0.001).
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