Key result
The combination of CTSD and CUX1 gene expression levels demonstrated outstanding capability in predicting the development of heart failure after acute myocardial infarction, with an AUC of 0.917.
Why the study?
Powerful biomarkers for early identification of AMI patients at risk of developing HF remain elusive.
Population
AMI patients who developed HF or did not, plus AMI and control mice
Comparison
Patients who developed HF vs those who did not, and AMI vs control mice
Design
Transcriptomic and single-cell RNA-sequencing bioinformatics analysis
Authors
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CUX1, CTSD, and ADD3 may support early post-AMI HF risk stratification; leaves open prospective validation before clinical adoption.
Observational (n=17)
Effect estimate: AUC 0.917 (95% CI 0.680-0.995)
p-value: p=<0.0001
Chen et al. (2021) conducted an observational in Acute myocardial infarction (AMI) at risk of heart failure (HF) (n=17). CTSD and CUX1 gene expression vs. Patients without post-AMI HF was evaluated on Prediction of post-AMI HF (AUC 0.917, 95% CI 0.680-0.995, p=<0.0001). The combination of CTSD and CUX1 gene expression levels demonstrated outstanding capability in predicting the development of heart failure after acute myocardial infarction, with an AUC of 0.917.
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