Key result
Among 100 hypertensive patients, only 29% exhibited prematurely elevated arterial rigidity indices for their age, indicating that premature arterial aging is not a universal consequence of hypertension.
Why the study?
Is premature arterial aging more prevalent in hypertensive patients, and what clinical factors are associated with it?
Cross-Sectional (n=100)
No
Is premature arterial aging more prevalent in hypertensive patients, and what clinical factors are associated with it?
Premature arterial aging in hypertensive patients is primarily associated with coexisting diabetes and prolonged hypertension duration, challenging the hypothesis that arterial rigidity is the primary cause of essential hypertension.
Arterial aging not universal in hypertension and links to diabetes/duration; leaves open its role as primary driver of essential hypertension.
Roach and Burton (1) described two important changes in arterial walls with advancing age. One is an increase in collagenous fibers causing loss of distensibility with increase in the slope dP/ dV of arterial pressure-volume curves. The other is a decrease in the unstretched length of these collagenous fibers as the "slack" in them is taken up, possibly by cross linkages and adhesions. This change results in a more rapid decrease in distensibility with stretch and an increase in the rate of change in slope (or the curvature) of pres- sure-volume curves toward the pressure axis.
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Abboud et al. (1961) conducted a cross-sectional in Hypertension (n=100). Hypertension vs. Age-matched normal limits was evaluated on Prematurely elevated arterial rigidity index. Among 100 hypertensive patients, only 29% exhibited prematurely elevated arterial rigidity indices for their age, indicating that premature arterial aging is not a universal consequence of hypertension.
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