Key result
The kinetic process of the conformational change of troponin-C induced by magnesium-binding or removal was biphasic, with a dissociation constant of 1 x 10(-3) M.
This basic science study elucidates the biphasic kinetic process and dissociation constant of magnesium binding to troponin-C in the absence of calcium.
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No clinical implications for magnesium therapy; leaves open troponin-C's in vivo role in contractility.
Iio et al. (1979) studied this question. Magnesium-binding or removal was evaluated on Kinetics of the conformational change of troponin-C. The kinetic process of the conformational change of troponin-C induced by magnesium-binding or removal was biphasic, with a dissociation constant of 1 x 10(-3) M.
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