Key result
Human epicardial fat exhibited decreased levels of HO-1-PGC1α mitochondrial signaling and increased levels of inflammatory adipokine CCN3 compared to visceral fat.
Why the study?
This study investigated whether levels of signaling pathways and inflammatory adipokines in epicardial fat regulate cardiovascular risks in humans and mice.
Increasing mitochondrial signaling via HO-1-PGC1α in epicardial fat may attenuate cardiometabolic dysfunction and improve left ventricular function, highlighting a potential therapeutic target for heart failure.
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May link epicardial adipokines to HF risk; hypothesis-generating and should not yet change practice.
Singh et al. (2019) studied Heart failure. Epicardial fat vs. Visceral fat was evaluated on Genetic profile and signaling pathways. Human epicardial fat exhibited decreased levels of HO-1-PGC1α mitochondrial signaling and increased levels of inflammatory adipokine CCN3 compared to visceral fat.