Key result
Intraoperative administration of 500 mL hydroxyethyl starch significantly decreased postoperative estimated glomerular filtration rate (71.17 vs 80.76 mL/min/1.73m2, p=0.01) compared to balanced electrolyte solutions in patients undergoing isolated coronary artery bypass graft surgery.
Why the study?
Hydroxyethyl starches increase renal injury risk in critically ill patients, and cardiac surgery patients are at risk for cardiac surgery-associated acute kidney injury, prompting an analysis of renal function with hydroxyethyl starches versus crystalloids in coronary surgery.
Does intraoperative administration of 500 mL hydroxyethyl starch reduce estimated glomerular filtration rate and impair renal function in patients undergoing isolated on-pump coronary artery bypass graft surgery?
Cohort (n=156)
No
Does intraoperative administration of 500 mL hydroxyethyl starch reduce estimated glomerular filtration rate and impair renal function in patients undergoing isolated on-pump coronary artery bypass graft surgery?
The intraoperative administration of 500 mL of hydroxyethyl starch during isolated on-pump CABG surgery is associated with a significant decrease in postoperative eGFR and an increase in serum creatinine.
Answers are grounded in this paper and cite their sources.
May warrant caution with hydroxyethyl starch in CABG; leaves open causal renal effects pending randomized trials.
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KOÇYİĞİT et al. (2022) conducted a cohort in Isolated on-pump coronary artery bypass graft surgery (n=156). Hydroxyethyl starch (HES) 130/0.4 vs. Balanced electrolyte solution (crystalloids) was evaluated on Postoperative estimated glomerular filtration rate (eGFR) (p=0.01). Intraoperative administration of 500 mL hydroxyethyl starch significantly decreased postoperative estimated glomerular filtration rate (71.17 vs 80.76 mL/min/1.73m2, p=0.01) compared to balanced electrolyte solutions in patients undergoing isolated coronary artery bypass graft surgery.
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