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This article reviews the historical and emerging clinical relevance of myocardial metabolism in cardiac surgery, congestive heart failure, and coronary occlusion.
A 1958 lecture reviewing the state of knowledge on myocardial metabolism and its relevance to cardiac surgery, congestive heart failure, and coronary occlusion.
1958 review of myocardial metabolism leaves open its therapeutic targeting in HF and surgery; prospective trials needed.
Article1 November 1958MYOCARDIAL METABOLISMR. J. BING, F.A.C.P., J. D. CHOUDHURY, G. MICHAL, K. KAKOR. J. BING, F.A.C.P., J. D. CHOUDHURY, G. MICHAL, K. KAKOAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-5-1201 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFor many years the study of cardiac metabolism has been of concern primarily to the physiologist working on the isolated heart and to the biochemist interested in the general aspects of intermediary metabolism.1, 2, 3, 4, 5, 6, 7Recently, the subject has also come to the attention of the surgeon and of the internist.8The former has had to concern himself with the oxygen consumption and the efficiency of the arrested heart during cardiac surgery, while the internist has begun to think about the heart muscle in its relation to congestive heart failure and coronary occlusion.9, 10In addition,...Bibliography1. 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Benson ES: Composition and state of protein in heart muscle of normal dogs and dogs with experimental myocardial failure, Circul. Res. 3: 221, 1955. CrossrefMedlineGoogle Scholar40. Rein vH: Uber ein Regulationssystem "Milz-Leber" für den oxydativen Stoffwechsel der Korpergewebe und besonders des Herzens, Naturwissenschaften 36: 260-268, 1949. CrossrefGoogle Scholar41. KakoChoudhuryBing KJDRJ: Mechanism of heart failure in the heart-lung preparation, in preparation. Google Scholar42. Huckabee WE: Relationship of pyruvate and lactate during anaerobic metabolism. I. Effect of infusion of pyruvate or glucose and hyperventilation, J. Clin. Investigation 37: 244, 1958. CrossrefMedlineGoogle Scholar43. Bing RJ: The role of coronary circulation in shock, Ann. New York Acad. Sc. 55: 367, 1952. CrossrefMedlineGoogle Scholar44. KarmenWroblewskiLaDue AFJS: Transaminase activity in human blood, J. Clin. Investigation 34: 126, 1955. CrossrefMedlineGoogle Scholar45. CabreraBeurenBing GARJ: Determinations of DPN (TPN), thiamine, amino acids and amino sugars in blood of animals with experimental myocardial infarction, Circul. Res. 6: 15, 1958. CrossrefMedlineGoogle Scholar46. EdwardsSiegelBing WSARJ: Studies on myocardial metabolism. III. Coronary blood flow, myocardial oxygen consumption and carbohydrate metabolism in experimental hemorrhagic shock, J. Clin. Investigation 33: 1646, 1954. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: St. Louis, Missouri*Presented as a Morning Lecture at the Thirty-ninth Annual Session of The American College of Physicians, Atlantic City, New Jersey, May 1, 1958.From the Department of Medicine, Washington University School of Medicine, and the Washington University Medical Service, Veterans Administration Hospital, St. Louis, Missouri.†Work supported by U. S. Public Health Service grant No. H-2678, The American Heart Association, The Life Insurance Medical Research Fund, and the Tobacco Industry Research Fund.Requests for reprints should be addressed to Richard J. Bing, M.D., Professor of Medicine, Washington University Medical Service, Veterans Administration Hospital, 915 North Grand Boulevard, St. Louis 6, Missouri. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCoronary Circulation and Cardiac MetabolismEtiopatogenesi unitaria della cardioangiopatia nel diabete mellitoEnhancement of Fatty Acid Oxidation and Medium-Chain Fatty Acyl Coenzyme A Synthetase by Adenine Nucleotides in Rat Heart HomogenatesRegelprobleme im Energiestoffwechsel des HerzmuskelsEffect of Chronic Poisoning by Emetine on Oxidative Process in Rat Heart III. 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Bing et al. (1958) conducted a review in Myocardial metabolism. This article reviews the historical and emerging clinical relevance of myocardial metabolism in cardiac surgery, congestive heart failure, and coronary occlusion.
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