What question did this study set out to answer?

Document the clinical presentation, metastatic spread, and histopathological features of an aggressive canine urothelial cell carcinoma exhibiting osseous metaplasia.

April 5, 2021Veterinary Record Case Reports

Urothelial cell carcinoma with widespread local and distant metastasis and associated osseous metaplasia in a dog

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Authors

TBThomas ButlerAlbert Einstein College of Medicine LSLuca SchiavoOncology Specialists KHKatherine HughesUniversity of Cambridge

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Implication

Case report demonstrates widespread metastatic urothelial cell carcinoma with pelvic osseous metaplasia in a dog, highlighting an atypical and aggressive presentation of canine urinary cancer.

Key Points

Document the clinical presentation, metastatic spread, and histopathological features of an aggressive canine urothelial cell carcinoma exhibiting osseous metaplasia.
Assessed a 9-year-old female neutered husky-cross presenting with bloody vaginal discharge and an inguinal mass using physical and ultrasonographic evaluations.
Performed post-mortem and histopathological examinations following euthanasia precipitated by sudden status epilepticus during sedation recovery.
Ultrasonography and necropsy revealed an extensive primary urothelial carcinoma spanning the vulva, bladder trigone, bladder neck, and proximal urethra.
Gross pathology confirmed widespread local and distant metastasis to the medial iliac lymph nodes, lungs, pelvic musculature, and inguinal dermis.
Histopathology identified osseous metaplasia intimately associated with neoplastic cellular aggregates located within the pelvic skeletal musculature.

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Butler et al. (2021) studied this question.

synapsesocial.com/papers/6a9b9d5fd8d8bde79ebb04e5 https://doi.org/10.1002/vrc2.67

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Implication

Case report demonstrates widespread metastatic urothelial cell carcinoma with pelvic osseous metaplasia in a dog, highlighting an atypical and aggressive presentation of canine urinary cancer.

Urothelial cell carcinoma with widespread local and distant metastasis and associated osseous metaplasia in a dog

Discussion

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Implication

Key Points

Cite This Study

Urothelial cell carcinoma with widespread local and distant metastasis and associated osseous metaplasia in a dog

Discussion

Member takes

Implication

Key Points

Cite This Study

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