In vitro study uncovers antibacterial activity of fungal indole alkaloids against methicillin-resistant Staphylococcus aureus, indicating potential inhibition of ELANE, MAOB, and STAT3.
Three undescribed indole alkaloids, fusarindoles F and G (1 and 2), and chlamydosporin B (3), together with five known compounds (4–8) were isolated from Robillarda sessilis. Their structures were elucidated based on NMR, UV, HRESIMS, and ECD calculation. Fusarindole F (1) own unusual asymmetric bis-indole structure. Compounds 5, 6, 7 exhibited moderate antibacterial activity against methicillin-resistant Staphylococcus aureus with a MIC value of 12.5 μg/mL. According to molecular docking experiment, the target proteins of compound 7 against methicillin-resistant S. aureus may be ELANE, MAOB and STAT3.
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Huang et al. (2024) studied this question.
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