Key result
Transcatheter aortic valve replacement reduced mortality by 50% and improved quality of life compared to medical therapy among elderly patients with inoperable aortic stenosis.
Why the study?
Does transcatheter aortic valve replacement improve mortality and quality of life in elderly patients with inoperable symptomatic aortic stenosis compared to medical therapy?
Does transcatheter aortic valve replacement improve mortality and quality of life in elderly patients with inoperable symptomatic aortic stenosis compared to medical therapy?
Transcatheter aortic valve replacement represents a breakthrough technology that significantly reduces mortality and improves quality of life in elderly patients with inoperable aortic stenosis.
P atients with symptomatic aortic stenosis have a poor prognosis, and medical therapy has little, if any, effect on their natural history.Surgical aortic valve replacement (AVR) is risky, yet it appears to be effective in extending life expectancy and reducing symptoms due to aortic stenosis.In this setting, the development of transcatheter AVR appears to be a breakthrough technology, potentially offering the benefits of surgical AVR without the need for an operation.1 Early clinical experience with transcatheter AVR has been promising and set the stage for a randomized trial to provide the definitive test of its efficacy.The concurrent PARTNER (Placement of AoRTic TraNscathetER Valves) trials 2,3 compared transcatheter AVR with medical therapy among patients at prohibitive risk of surgery (PARTNER cohort B), and compared transcatheter and surgical AVR among patients at high, but acceptable risk of surgery (PARTNER cohort A).The PARTNER cohort B trial showed that transcatheter AVR reduced mortality by 50% among inoperable patients and also improved quality of life. 2 Transcatheter AVR was clearly a great improvement over medical therapy among elderly patients (average age of 83 years) with inoperable aortic stenosis.
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Hlatky et al. (2012) conducted an editorial in symptomatic aortic stenosis. Transcatheter aortic valve replacement vs. Medical therapy or surgical aortic valve replacement was evaluated on Mortality (50% reduction). Transcatheter aortic valve replacement reduced mortality by 50% and improved quality of life compared to medical therapy among elderly patients with inoperable aortic stenosis.
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