Key result
In the presence of nicotine tobacco smoking, greater mass doses of the PET ligand carfentanil significantly decreased peak cortisol levels (p=0.002), while raclopride increased peak prolactin levels (p=0.003).
Why the study?
Do carfentanil and raclopride mass doses affect venous plasma cortisol and prolactin levels after tobacco smoking during PET scanning?
Do carfentanil and raclopride mass doses affect venous plasma cortisol and prolactin levels after tobacco smoking during PET scanning?
p-value: p=<0.05
Carfentanil and raclopride doses differentially modulate cortisol and prolactin responses to tobacco smoking during PET scanning.
Carfentanil may blunt cortisol responses to nicotine smoking; leaves open clinical relevance and requires prospective confirmation.
Peak cortisol levels after average nicotine (avnic) tobacco smoking were decreased with greater carfentanil doses (p = 0.03). The change in plasma cortisol levels after avnic smoking compared to before avnic smoking was also decreased with greater carfentanil doses (p = 0.003). Unexpectedly the changes in cortisol levels after denicitinized (denic) tobacco smoking compared to before denic smoking were increased with greater carfentanil doses (p = 0.04). No dose effects of raclopride were found on cortisol levels. Peak prolactin levels after avnic smoking were increased with greater raclopride doses (p = 0.003). The changes in prolactin levels after avnic smoking compared to before were also increased with greater doses of raclopride (p < 0.001). There was no effect of carfentanil on plasma prolactin.
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Edward F. Domino (2016) studied Healthy smokers (n=24). [11C] carfentanil and [11C] raclopride vs. Basal hormone levels (before smoking) was evaluated on Correlation between radioligand mass doses and venous plasma cortisol and prolactin levels (p=<0.05). In the presence of nicotine tobacco smoking, greater mass doses of the PET ligand carfentanil significantly decreased peak cortisol levels (p=0.002), while raclopride increased peak prolactin levels (p=0.003).
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