What question did this study set out to answer?

To assess whether serum uric acid levels modulate the relationship between cerebrospinal fluid Alzheimer's disease biomarkers and longitudinal cognitive decline.

February 24, 2016European Journal of NeurologyOpen Access

Does serum uric acid act as a modulator of cerebrospinal fluid Alzheimer's disease biomarker related cognitive decline?

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Authors

BYByoung Seok YeYonsei University WLWonwoo LeeYonsei University JHJee Hyun HamYonsei University

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Implication

Cohort study reveals higher serum uric acid slows cognitive decline in Alzheimer disease and mild cognitive impairment, suggesting a protective role against biomarker-driven neurodegeneration.

Key Points

To assess whether serum uric acid levels modulate the relationship between cerebrospinal fluid Alzheimer's disease biomarkers and longitudinal cognitive decline.
Evaluated 271 healthy individuals, 596 patients with mild cognitive impairment, and 197 patients with Alzheimer's disease from the Alzheimer's Disease Neuroimaging Initiative database.
Measured baseline serum uric acid and cerebrospinal fluid biomarkers (Aβ1-42 and tau), assessing cognition serially via MMSE and ADAS-cog over a mean duration of 2.9 years.
Applied sex-stratified linear mixed effect models to determine the independent and interactive effects of uric acid and biomarkers on longitudinal cognitive performance.
Higher baseline serum uric acid was associated with slower longitudinal cognitive decline, an effect most prominent in mild cognitive impairment and dementia subgroups as well as female participants.
In interaction models, higher uric acid levels attenuated the detrimental effect of cerebrospinal fluid Aβ1-42 on cognitive decline across subjects.
Higher uric acid levels mitigated the adverse cognitive effect of cerebrospinal fluid tau specifically in female subjects, but this interaction was not observed in male subjects.

Cite This Study

Ye et al. (2016) studied this question.

synapsesocial.com/papers/6a9ba5ca2c9fe64af7025aed https://doi.org/10.1111/ene.12969

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Implication

Cohort study reveals higher serum uric acid slows cognitive decline in Alzheimer disease and mild cognitive impairment, suggesting a protective role against biomarker-driven neurodegeneration.

Does serum uric acid act as a modulator of cerebrospinal fluid Alzheimer's disease biomarker related cognitive decline?

Discussion

Member takes

Implication

Key Points

Cite This Study

Does serum uric acid act as a modulator of cerebrospinal fluid Alzheimer's disease biomarker related cognitive decline?

Discussion

Member takes

Implication

Key Points

Cite This Study

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