Key result
Post-polio patients with chronic neurologic disease had higher mean serum creatine kinase levels than controls without neurologic compromise.
Cross-Sectional (n=75)
Post-polio patients with chronic neurologic disease have significantly higher serum creatine kinase levels that correlate with physical activity, suggesting chronic muscle overuse may contribute to advanced senescence.
Answers are grounded in this paper and cite their sources.
May signal muscle overuse in post-polio patients; leaves open contribution to senescence.
Elevated creatine kinase (CK) levels may be noted in neuromuscular patients as a result of muscle damage and necrosis. We measured the serum CK levels of 62 post-polio patients with chronic neurologic disease (Neuro) and 13 post-polio patients with no evidence of neurologic compromise (Control). Patient groups were comparable for age, gender and years since onset of poliomyelitis. The Neuro group had substantially increased CK levels compared with the Control group, 211 +/- 19.0 IU v 114 +/- 26.2 IU (mean +/- 1 SE; P less than 0.05). Of the Neuro group, 40% had abnormally elevated CK values, compared with 8% of the Control group. Within the Neuro group, there was a robust correlation between elevated CK values and self-reports of strenuous work and level of community ambulation (P less than 0.05). These findings support the hypothesis that chronic muscle overuse may be a contributing factor to the advanced senescence reported by post-polio patients with neuromuscular compromise.
No takes yet. Share an insight, caveat, or question.
Waring et al. (1989) conducted a cross-sectional in Post-polio (n=75). Chronic neurologic disease vs. No evidence of neurologic compromise was evaluated on Serum creatine kinase (CK) levels (IU) (p=<0.05). Post-polio patients with chronic neurologic disease had higher mean serum creatine kinase levels than controls without neurologic compromise.
Synapse has enriched 10 related papers. Consider them for comparative context: