Key result
Patients with familial hypercholesterolemia had lower quality of life scores compared to healthy controls in both the physical and mental components.
Why the study?
Alimentation is a key factor in familial hypercholesterolemia, and implementing a restrictive diet alongside social and environmental factors may significantly impact quality of life.
Are eating patterns and familial hypercholesterolemia associated with a lower quality of life compared to healthy controls?
Observational (n=90)
No
Are eating patterns and familial hypercholesterolemia associated with a lower quality of life compared to healthy controls?
Patients with familial hypercholesterolemia exhibit lower physical and mental quality of life, which is associated with overeating driven by boredom, highlighting the need for multidisciplinary management.
Answers are grounded in this paper and cite their sources.
FH patients show lower physical and mental QoL; hypothesis-generating for eating pattern links and requires prospective confirmation before guiding care.
(1) Background: Familial hypercholesterolemia (FH) is a genetic disease that has autosomal dominant inheritance, being characterized by increased levels of low-density lipoproteins (LDLs) due to a decreased clearance of the circulant LDLs. Alimentation is a key factor in patients with FH. Implementing a restrictive diet may have a significant impact on their quality of life, besides the social and environmental factors. (2) Methods: We realized a prospective study that was conducted in the Cardiovascular Rehabilitation Clinic from the Clinical Rehabilitation Hospital and that included 70 patients with FH and 20 controls (adults with no comorbidities). We evaluated their lipid profile, their quality of life through the Short Form-36 Questionnaire, and their eating habits. (3) Results: Lower scores in the quality-of-life questionnaire were obtained in the FH group both in the case of the physical (73.06 vs. 87.62) and the mental component (75.95 vs. 83.10). Women had better physical function (85 vs. 75) and physical role than men (100 vs. 75). The group aged over 65 has the score lowest for all 10 components. Overeating was driven by boredom and was more frequent on weekends in the FH group. None of the patients in the control group felt loneliness or depression associated with overeating. (4) Conclusions: Overeating in patients with FH is associated with a lower quality of life. The complexity of these patients needs a multidisciplinary approach. Thus, the quality-of-life questionnaire should be implemented in their periodic follow-ups in order to increase their general status, paying special attention to geriatric patients.
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Maștaleru et al. (2023) conducted an observational in Familial Hypercholesterolemia (n=90). Familial Hypercholesterolemia vs. Healthy controls was evaluated on SF-36 Physical component score (p=<0.001). Patients with familial hypercholesterolemia had lower quality of life scores compared to healthy controls in both the physical and mental components.
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