Key result
Examination of 11 failed formalin-treated heterograft porcine aortic valves showed failure was due to cusp stretching and deformation from reduced collagen, indicating limited durability.
Population
33 patients at Groote Schuur Hospital who had their mitral valve replaced by a pig aortic valve
Comparison
Formalin-treated heterograft porcine aortic… vs Control pig aortic valves
Design
Case_series
Follow-up
2 to 32 months
Authors
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Suggests limited durability of formalin-treated heterografts; leaves open questions on fixation methods for modern bioprostheses.
Observational (n=33)
No
Formalin-treated heterograft porcine aortic valves in the mitral position have limited durability due to collagen reduction leading to cusp stretching and valvular incompetence.
Alan G. Rose (1972) conducted an observational in Mitral valve replacement (n=33). Formalin-treated heterograft porcine aortic valve vs. Control pig aortic valves was evaluated on Pathological cause of valve failure. Examination of 11 failed formalin-treated heterograft porcine aortic valves showed failure was due to cusp stretching and deformation from reduced collagen, indicating limited durability.
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