Key result
Furosemide use in end-stage renal disease patients on dialysis with residual diuresis was correlated with improved cardiac parameters assessed by echocardiography.
Why the study?
In dialysis patients, the efficacy of furosemide and its cardiovascular hemodynamic effects are unclear, given pharmacokinetic changes requiring higher doses in impaired renal clearance.
Does furosemide use improve cardiovascular hemodynamics in end-stage renal disease patients on hemodialysis?
Observational
Does furosemide use improve cardiovascular hemodynamics in end-stage renal disease patients on hemodialysis?
Furosemide use is associated with improved echocardiographic cardiac parameters in hemodialysis patients with residual diuresis, suggesting complementary cardiovascular benefits.
Furosemide efficiency in dialysis remains unclear; leaves open prospective trials on vascular and hemodynamic effects.
Furosemide is a drug that has not only a renal effect, but also a vascular one, resulting in decreased left atrial and ventricularfilling pressure accompanied by an increase in venous compliance, all of this with significant effects on central cardiac hemodynamics.In dialysis patients, it is still unclear the efficiency of furosemide, a diuretic drug that inhibits the Na+, K+, 2CL� cotransporter in the renal tubular system. Also, furosemide need to be used at much higher doses because of its pharmacokinetic changes in the context of impaired renal clearance.The aim of our study was to investigate whether furosemide induces changes in cardiovascular hemodynamics in end-stage renal disease (ESRD) patients, using standard echocardiography and Tissue Doppler Imaging (TDI).We foundcorrelations between furosemide useand improved cardiac parameters, assessed by multiple echocardiographic variables, and we consider that furosemide has complementary effects in dialysis patients with residual diuresis.
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Albulescu et al. (2019) conducted an observational in End-stage renal disease (ESRD) on hemodialysis. Furosemide was evaluated on Changes in cardiovascular hemodynamics assessed by echocardiography and Tissue Doppler Imaging (TDI). Furosemide use in end-stage renal disease patients on dialysis with residual diuresis was correlated with improved cardiac parameters assessed by echocardiography.
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