Key result
MCI-154 increased developed tension in a dose-dependent manner and reduced the inward rectifier K+ current at higher concentrations in guinea pig ventricular cells.
Population
Isolated papillary muscles and single ventricular cells of the guinea pig heart
Design
Preclinical
Authors
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MCI-154 may boost contractility partly via IK1 reduction in isolated cells; leaves open in vivo efficacy and human translation.
The positive inotropic action of the novel cardiotonic drug MCI-154 is partially explained by a decrease in the inward rectifier K+ current and likely an increase in Ca2+ sensitivity of the contractile protein system.
KATAYAMA et al. (1987) studied this question. MCI-154 was evaluated on Membrane potential, currents, and developed tension. MCI-154 increased developed tension in a dose-dependent manner and reduced the inward rectifier K+ current at higher concentrations in guinea pig ventricular cells.
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