Key result
A robust isolation and culture protocol successfully generated three distinct stem cell populations (cardiac progenitor, endothelial progenitor, and mesenchymal) from a single human heart biopsy.
Population
Human heart tissue samples obtained during implantation of a left ventricular assist device in heart failure…
Design
Preclinical
Authors
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May enable autologous multi-lineage cell sourcing from minimal tissue; leaves open clinical translation and efficacy trials.
A robust protocol was established to concurrently isolate three distinct endogenous cardiac stem cell populations from a single human heart biopsy, enabling further research into myocardial regeneration.
Monsanto et al. (2017) studied Heart failure. Protocol for isolation of 3 distinct cardiac stem cell populations was evaluated on Successful concurrent isolation and expansion of cardiac progenitor cells, endothelial progenitor cells, and mesenchymal stem cells from a single tissue sample. A robust isolation and culture protocol successfully generated three distinct stem cell populations (cardiac progenitor, endothelial progenitor, and mesenchymal) from a single human heart biopsy.
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