Key result
Nitration of the tyrosine residue of angiotensin II by peroxynitrite totally inhibits its vasoconstrictive properties, whereas transformations of the arginine residue do not alter them.
Population
Angiotensin II peptide (in vitro) and in vivo models
Design
Preclinical
Authors
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Should not change practice; leaves open peroxynitrite's role in human Ang II regulation.
Nitration of the tyrosine residue of angiotensin II by peroxynitrite abolishes its vasoconstrictive properties, highlighting a potential mechanism for blood pressure regulation by reactive nitrogen species.
Ducrocq et al. (1998) studied this question. Nitrogen oxides (NO, HNO2, peroxynitrite) was evaluated on Chemical modifications of angiotensin II and vasoconstrictive properties. Nitration of the tyrosine residue of angiotensin II by peroxynitrite totally inhibits its vasoconstrictive properties, whereas transformations of the arginine residue do not alter them.
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