Key result
Increases in blood flow caused endothelium-dependent increases in arterial diameter, which were abolished by L-NAME and absent in endothelium-damaged arteries.
Population
Anaesthetized dog preparation
Comparison
Transient and maintained increases in blood flow… vs Artery section with damaged endothelium compared…
Design
Preclinical
Authors
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Should not inform clinical vascular management; extends foundational evidence for endothelium-dependent flow dilation in animal models.
Flow-induced vasodilation in the iliac artery is dependent on intact endothelium and the release of endothelium-derived relaxing factor, causing a 29% reduction in calculated boundary wall shear stress.
Snow et al. (1994) studied this question. Increase in blood flow vs. Damaged endothelium / L-NAME administration was evaluated on Change in arterial diameter. Increases in blood flow caused endothelium-dependent increases in arterial diameter, which were abolished by L-NAME and absent in endothelium-damaged arteries.
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