Population
Anaesthetized pigs (in vivo model)
Design
Preclinical
Authors
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Hypothesis-generating for shear-mediated NO responses in atheroma; leaves open human translation and should not alter practice.
The study demonstrates that mean wall shear stress promotes NO-mediated vasodilation, while pulsatile shear stress amplitude slightly inhibits it, providing a potential mechanism for the uneven distribution of atheroma.
H. M. Snow (2007) studied this question.
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