Key result
Increased intraluminal flow drives endothelium-dependent dilation via shear stress, but extreme tone causes constriction.
Population
Animals and man (specifically referencing rabbit basilar artery models)
Design
Review
Authors
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Predominant shear stress dilation informs vascular models; leaves open clinical translation in microvascular disease.
This review highlights the complex interplay between endothelial potassium channels and smooth muscle calcium channels in regulating vascular tone in response to shear stress.
JA. Bevan (2008) conducted a review in Vascular tone and shear stress. Increased intraluminal flow (shear stress) was evaluated on Vascular diameter change (dilation or constriction). Increased intraluminal flow predominantly initiates endothelium-dependent dilation via shear stress, though extreme levels of vascular tone can result in constriction.
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