September 23, 2008Blood Vessels

Mechanoreception by the Endothelium: Mediators and Mechanisms of Pressure- and Flow-Induced Vascular Responses

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Population

Blood vessels (endothelium and vascular smooth muscle)

Design

Review

Authors

GRGabor M. RubanyiVascular / Pulmonary Vascular AFAna D. FreayUniversity of Miami KKKatalin KauserSemmelweis University

Discussion

Member takes

Implication

Informs clinical interpretation of endothelial function tests; leaves open mechanosensor-targeted interventions in vascular disease.

Structured PICO

Population

Blood vessels (endothelium and vascular smooth muscle)

Intervention

Changes in physical forces (transmural pressure or flow velocity/shear stress)

Outcome

Changes in blood vessel diameter (contraction and relaxation of vascular smooth muscle)surrogate

The endothelium acts as a mechanosensor, transducing changes in pressure and shear stress into vascular responses via the release of vasoactive factors.

Cite This Study

Rubanyi et al. (2008) studied this question.

synapsesocial.com/papers/6a762bb4d5b06e2c1e614a0a https://doi.org/10.1159/000158816

View Full Paper

Ask AI

Bookmark

Mechanoreception by the Endothelium: Mediators and Mechanisms of Pressure- and Flow-Induced Vascular Responses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanoreception by the Endothelium: Mediators and Mechanisms of Pressure- and Flow-Induced Vascular Responses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider