Key result
At 5 years after bariatric surgery, the prevalence of significant weight regain varied widely from 16% to 37% depending on the definition applied, while 87% of patients experienced any weight regain.
Why the study?
The prevalence and clinical significance of weight regain after bariatric surgery remain unclear due to the lack of a standardized definition.
How do different definitions of weight regain after bariatric surgery affect the reported prevalence and associations with clinical outcomes?
Cohort (n=868)
Yes
How do different definitions of weight regain after bariatric surgery affect the reported prevalence and associations with clinical outcomes?
The prevalence of clinically significant weight regain after bariatric surgery varies widely (16-37%) depending on the definition used, highlighting the need for a standardized definition incorporating weight, HRQoL, and comorbidity remission.
Answers are grounded in this paper and cite their sources.
Different WR definitions yield 2-94% rates at 5 years post-SG with varying outcome links; leaves open optimal metric for monitoring or trials.
INTRODUCTION: The prevalence and clinical significance of weight regain after bariatric surgery remains largely unclear due to the lack of a standardized definition of significant weight regain. The development of a clinically relevant definition of weight regain requires a better understanding of its clinical significance. OBJECTIVES: To assess rates of weight regain 5 years after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG), applying six definitions and investigating their association with clinical outcomes. METHODS: Patients were followed up until 5 years after surgery and weight regain was calculated. Regression techniques were used to assess the association of weight regain with health-related quality of life (HRQoL) and the presence of comorbidities. RESULTS: and the total maximum weight loss was 32% (± 8%). Eighty-seven percent experienced any regain. Significant weight regain rates ranged from 16 to 37% depending on the definition. Three weight regain definitions were associated with deterioration in physical HRQoL (p < 0.05), while associations between definitions of weight regain and the presence of comorbidities 5 years after surgery were not significant. CONCLUSION: These results indicate that identifying one single categorical definition of clinically significant weight regain is difficult. Additional research into the clinical significance of weight regain is needed to inform the development of a standardized definition that includes all dimensions of surgery success: weight, HRQoL, and comorbidity remission.
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Voorwinde et al. (2019) conducted a cohort in Extreme obesity (post-bariatric surgery) (n=868). Different definitions of weight regain was evaluated on Prevalence of weight regain 5 years after bariatric surgery according to six different definitions. At 5 years after bariatric surgery, the prevalence of significant weight regain varied widely from 16% to 37% depending on the definition applied, while 87% of patients experienced any weight regain.
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