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November 1, 2019Obesity SurgeryOpen Access

Definitions of Long-Term Weight Regain and Their Associations with Clinical Outcomes

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Key result

At 5 years after bariatric surgery, the prevalence of significant weight regain varied widely from 16% to 37% depending on the definition applied, while 87% of patients experienced any weight regain.

Why the study?

The prevalence and clinical significance of weight regain after bariatric surgery remain unclear due to the lack of a standardized definition.

How do different definitions of weight regain after bariatric surgery affect the reported prevalence and associations with clinical outcomes?

Population

Patients after Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG)

Comparison

Six definitions of weight regain

Follow-up

5 years

Authors

VVVera VoorwindeISIngrid HM SteenhuisIJIgnace M. C. Janssen

Discussion

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Member takes

Overview

Different WR definitions yield 2-94% rates at 5 years post-SG with varying outcome links; leaves open optimal metric for monitoring or trials.

Study Design

Type

Cohort (n=868)

Multicenter

Yes

Structured PICO

How do different definitions of weight regain after bariatric surgery affect the reported prevalence and associations with clinical outcomes?

P
Population
868 patients with extreme obesity who underwent primary Roux-en-Y gastric bypass or sleeve gastrectomy, followed for 5 years to assess the prevalence and clinical significance of weight regain.
E
Exposure
Bariatric surgery (Roux-en-Y gastric bypass or sleeve gastrectomy) followed by a multidisciplinary treatment program
O
Outcome
Rates of weight regain 5 years after surgery applying six definitions, and their association with health-related quality of life (HRQoL) and comorbiditiessurrogate

The prevalence of clinically significant weight regain after bariatric surgery varies widely (16-37%) depending on the definition used, highlighting the need for a standardized definition incorporating weight, HRQoL, and comorbidity remission.

Limitations

  • High loss to follow-up rate of 65% at 5 years after surgery.
  • Reliance on self-reported measures for patients completing the online questionnaire.
  • Lack of HbA1c and cholesterol measurements to objectively assess comorbidity status.
  • Relatively small proportion of patients who underwent sleeve gastrectomy.
  • Loss to follow-up rate of 65%
  • HbA1c and cholesterol measures were not available, relying on patient-reported medication use and blood pressure at follow-up

Cite This Study

Voorwinde et al. (2019) conducted a cohort in Extreme obesity (post-bariatric surgery) (n=868). Different definitions of weight regain was evaluated on Prevalence of weight regain 5 years after bariatric surgery according to six different definitions. At 5 years after bariatric surgery, the prevalence of significant weight regain varied widely from 16% to 37% depending on the definition applied, while 87% of patients experienced any weight regain.

synapsesocial.com/papers/6a9bcac82cbd83484d8ff130https://doi.org/10.1007/s11695-019-04210-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ten-Year Weight Regain After Bariatric Surgery: Prevalence, Predictors, and Metabolic Impact2025
  2. 2Patient Behaviors and Characteristics Related to Weight Regain After Roux-en-Y Gastric Bypass2019 · 92 citations
  3. 3Surgical approach of weight regain after bariatric surgery2020 · 8 citations
  4. 4Weight regain after Roux-en-Y gastric bypass has a large negative impact on the Bariatric Quality of Life Index2017 · 71 citations
  5. 5Determinants of Weight Loss and Regain in Men After Roux-En-Y Gastric Bypass: A Retrospective Analysis2025