Key result
In young men with premature androgenetic alopecia, the prevalence of metabolic syndrome was 8%, showing no increase compared to the general population, though alopecia severity positively correlated with metabolic syndrome.
Cross-Sectional (n=75)
No
In young men with premature androgenetic alopecia, the prevalence of metabolic syndrome was not significantly increased compared to the general population, and no premature coronary artery disease was detected.
Does not support routine metabolic screening or CAD evaluation in young men with premature AGA; leaves open any association using modified criteria for prospective study.
Background: Androgenetic alopecia (AGA) is a common form of patterned hair loss characterized by transformation of terminal hair of the scalp to vellous hair mediated mainly by androgens. Premature androgenetic alopecia can be defined as androgenetic alopecia developing before 35 years of age and presenting with at least stage 2 of Norwood-Hamilton classification. Premature AGA not only adds to psychological stress but is also reported as a risk factor for cardiovascular diseases, metabolic syndrome and carcinoma prostrate. In many subsequent studies, AGA has been shown to be associated with several diseases such as insulin resistance (IR), abnormal serum lipid profiles and obesity. Methods: Various parameters of metabolic syndrome were measured in 75 male patients of AGA in the department of dermatology, Safdarjung hospital from June 2015 to April 2016. ECG and echocardiography was done in all patients to look for any evidence of premature coronary artery disease. Results: In our study grade III and IV of AGA were the most common types (32% each). We found the prevalence of metabolic syndrome to be 8% in our patients with premature androgenetic alopecia in accordance with the NCEP ATP III guidelines. There was a significant positive correlation between grade of androgenetic alopecia and metabolic syndorme in our patients (p=0.049). Conclusions: The prevalence of metabolic syndrome was not increased as compared to general population.
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Batra et al. (2017) conducted a cross-sectional in Premature androgenetic alopecia (n=75). Premature androgenetic alopecia was evaluated on Prevalence of metabolic syndrome (r=0.22, p=0.049). In young men with premature androgenetic alopecia, the prevalence of metabolic syndrome was 8%, showing no increase compared to the general population, though alopecia severity positively correlated with metabolic syndrome.
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