Key result
Early-onset androgenetic alopecia in young men was associated with a significantly higher frequency of metabolic syndrome compared to matched controls (11.9% vs 3.0%; p=0.016).
Why the study?
Is early-onset androgenetic alopecia associated with an increased frequency of metabolic syndrome in young men?
Case-Control (n=202)
No
Is early-onset androgenetic alopecia associated with an increased frequency of metabolic syndrome in young men?
Absolute Event Rate: 11.9% vs 3%
p-value: p=0.016
Early-onset androgenetic alopecia in young men is significantly associated with metabolic syndrome, suggesting it may serve as an early clinical marker for cardiovascular risk.
Hypothesis-generating for metabolic syndrome evaluation in young men with early-onset androgenetic alopecia; leaves open cardiovascular outcome prediction.
OBJECTIVE: To evaluate the association of early-onset AGA (androgenetic alopecia) and metabolic syndrome in the younger male population. STUDY DESIGN: Case-control study. PLACE AND DURATION OF STUDY: Department of Dermatology, Mayo Hospital Lahore, from October 2017 to March 2018. METHODOLOGY: A total of 202 patients were enrolled, 101 male patients with early-onset AGA (cases with a alopecia between 20-36 years of age), and were matched with 101 controls. All measurements regarding BMI, metabolic syndrome, and grades of alopecia were recorded on a pre-designed proforma. RESULTS: Of the 101 cases (mean age 27.77 ± 5.04 years), 27 (26.7%) had grade 3, 41 (40.6%) had grade 4, 29 (28.7%) had grade 5 and 4 (4%) had grade 6 AGA. Patients of AGA had an approximate four times increased frequency of metabolic syndrome. Of the cases 12 (11.9%) had metabolic syndrome whereas it was found in 3 (3%) of the control group. A significant association was found between cases of AGA and metabolic syndrome (p=0.016). CONCLUSION: This study suggests a significant association of AGA with metabolic syndrome.
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Butt et al. (2021) conducted a case-control in Early-onset androgenetic alopecia (n=202). Early-onset androgenetic alopecia vs. Matched controls without early-onset androgenetic alopecia was evaluated on Metabolic syndrome (p=0.016). Early-onset androgenetic alopecia in young men was associated with a significantly higher frequency of metabolic syndrome compared to matched controls (11.9% vs 3.0%; p=0.016).
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