Key result
Androgenetic alopecia is linked to ~246% higher risk of metabolic syndrome versus healthy controls.
Why the study?
Studies evaluating the association between androgenetic alopecia and metabolic syndrome have yielded conflicting results.
Is androgenetic alopecia associated with an increased risk of metabolic syndrome?
Meta-Analysis (n=2,531)
Is androgenetic alopecia associated with an increased risk of metabolic syndrome?
Patients with androgenetic alopecia have a significantly higher risk of metabolic syndrome and poorer metabolic profiles, suggesting a need for metabolic screening in this population.
Answers are grounded in this paper and cite their sources.
May warrant metabolic screening in androgenetic alopecia; confirms association across observational meta-analyses.
The association of androgenetic alopecia with metabolic syndrome has been investigated in several studies, with conflicting results. We conducted a meta-analysis to quantitatively evaluate the risk grade of metabolic syndrome and the metabolic profile in patients with androgenetic alopecia compared with controls. In total, 19 articles (2,531 participants) satisfied the inclusion criteria. The pooled odds ratio for the prevalence rate of metabolic syndrome between the group with androgenetic alopecia and controls was 3.46 (95% CI 2.38-5.05; p < 0.001). Female sex, early onset, and African ethnicity were associated with an increased risk of metabolic syndrome. Furthermore, patients with androgenetic alopecia had significantly poorer metabolic profiles, such as body mass index, waist circumference, fasting glucose, blood lipids, and blood pressure. It is important for physicians to screen metabolism-related indicators in patients with androgenetic alopecia. More rigorously designed studies and larger sample sizes are required in future studies.
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Qiu et al. (2021) conducted a meta-analysis in Androgenetic Alopecia and Metabolic Syndrome (n=2,531). Androgenetic alopecia vs. Healthy controls (without androgenetic alopecia) was evaluated on Prevalence rate of metabolic syndrome (OR 3.46, 95% CI 2.38-5.05, p=<0.001). Androgenetic alopecia was associated with a significantly increased risk of metabolic syndrome compared to healthy controls (OR 3.46).
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