Key result
Progressive hypoxia in calves increased pulmonary blood pressure, resistance, and wave reflections, including a 30% increase in main pulmonary artery pulse wave velocity with prolonged hypoxia.
Why the study?
Does progressive hypoxia alter pulmonary vascular impedance and wave reflections in open-chest calves?
Population
four open-chest calves
Design
Preclinical
Authors
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May increase right ventricular afterload in hypoxia; leaves open translation from calf model to human disease.
Does progressive hypoxia alter pulmonary vascular impedance and wave reflections in open-chest calves?
Hypoxia induces complex alterations in pulmonary artery elasticity and wave reflections, increasing the oscillatory afterload of the right ventricle in a calf model.
Zuckerman et al. (1992) studied Hypoxic pulmonary vasoconstriction (n=4). Progressive hypoxia was evaluated on Main pulmonary artery impedance and pressure transmission spectra. Progressive hypoxia in calves increased pulmonary blood pressure, resistance, and wave reflections, including a 30% increase in main pulmonary artery pulse wave velocity with prolonged hypoxia.
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