July 1, 1994AJP Heart and Circulatory Physiology

Effects of chronically elevated pulmonary arterial pressure and flow on right ventricular afterload

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Population

Control lambs and two lamb models of altered pulmonary hemodynamics induced at infancy

Comparison

Elevated pulmonary arterial pressure or elevated… vs Control lambs

Design

Preclinical

Authors

BHB. HaMinzu University of China CLCarol L. LucasUniversity of North Carolina at Chapel Hill GHG. William HenryUniversity of North Carolina at Chapel Hill

Discussion

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Implication

Early wave reflection may worsen RV loading in PH; animal data leave open human translation and therapeutic targeting.

Structured PICO

Population

Control lambs and two lamb models of altered pulmonary hemodynamics induced at infancy (MCTP-induced elevated pulmonary arterial pressure and AV fistula-induced elevated pulmonary arterial blood flow)

Intervention

Elevated pulmonary arterial pressure (MCTP model) or elevated pulmonary arterial blood flow (Shunt model)

Comparator

Control lambs

Outcome

Pulmonary input impedance and indexes quantifying the timing of the reflected wave pulsesurrogate

In a lamb model of pulmonary hypertension, early wave reflection unfavorably loads the right ventricle during ejection, contributing to detrimental hemodynamics.

Cite This Study

Ha et al. (1994) studied this question.

synapsesocial.com/papers/6a70b967f44fa9f079de6ac6 https://doi.org/10.1152/ajpheart.1994.267.1.h155

View Full Paper

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Effects of chronically elevated pulmonary arterial pressure and flow on right ventricular afterload

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of chronically elevated pulmonary arterial pressure and flow on right ventricular afterload

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider