Key result
In fetal lambs, systolic pulmonary trunk pressure exceeded aortic pressure (maximal difference 6.5 +/- 2.5 mmHg, P<0.001), driven by right ventricular contraction and pulmonary vascular waves.
Population
9 anesthetized late-gestation fetal sheep
Design
Preclinical
Authors
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Challenges fetal pressure assumptions in animal models; leaves open human translation pending clinical validation.
p-value: p=<0.001
The higher pulmonary trunk than aortic blood pressure in fetal lambs is a systolic phenomenon driven by right ventricular pump function and a pressure-increasing energy wave from the fetal pulmonary vasculature.
Smolich et al. (2010) studied Fetal pulmonary trunk vs aortic trunk pressure difference (n=9). Wave intensity analysis of right ventricular and pulmonary vascular contributions was evaluated on Systolic pulmonary trunk (PT) versus aortic trunk (AoT) pressure difference (p=<0.001). In fetal lambs, systolic pulmonary trunk pressure exceeded aortic pressure (maximal difference 6.5 +/- 2.5 mmHg, P<0.001), driven by right ventricular contraction and pulmonary vascular waves.
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