Key result
At baseline, 83% of mean pulmonary trunk flow crossed the ductus arteriosus and 17% entered the lungs, with complex phasic interactions driven by characteristic impedance and wave reflections.
Population
10 anesthetized late-gestation fetal sheep instrumented with pulmonary trunk, ductus arteriosus, and left…
Comparison
Flow profile and wave intensity analyses during… vs Baseline flow profile and wave intensity analyses
Design
Preclinical
Authors
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Details fetal pulmonary flow in sheep; leaves open human translation and clinical relevance.
This study elucidates the complex phasic hemodynamics of fetal pulmonary circulation, showing that early systolic flow favors the pulmonary artery while mid-to-late systolic flow favors the ductus arteriosus due to wave reflection.
Smolich et al. (2011) studied Fetal blood flow dynamics (n=10). Flow profile and wave intensity analyses during extrasystole vs. Baseline was evaluated on Distribution of mean pulmonary trunk flow and phasic flow patterns. At baseline, 83% of mean pulmonary trunk flow crossed the ductus arteriosus and 17% entered the lungs, with complex phasic interactions driven by characteristic impedance and wave reflections.