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September 5, 2026Quality of Life ResearchOpen Access

Capturing quality of life in pouch anal and vaginal fistula: development of PAVF-QoL-14, a patient-reported outcome measure

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Authors

LRLillian RezaLALaith AlrubaiyLBLara Bapir

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Overview

Validation study reveals high reliability of the PAVF-QoL-14 scale in patients with pouch anal and vaginal fistulas, highlighting its value for clinical assessment.

Key Points

  • To develop and validate a disease-specific, 14-item patient-reported outcome measure assessing quality of life in individuals with pouch anal and vaginal fistulas.
  • Followed COSMIN guidelines, combining a systematic literature review and semi-structured patient interviews (n = 14) with expert reviews and cognitive interviews (n = 10) to draft and refine items.
  • Conducted psychometric evaluation and test–retest reliability analysis in a cohort of 76 patients.
  • Assessed internal consistency, factor structure using principal component analysis, and construct validity against the Hospital Anxiety and Depression Scale (HADS) and Short-Form 12 (SF-12).
  • Principal component analysis identified four domains (symptoms, discharge, faecal incontinence, and future concerns) accounting for 63.7% of total variance (KMO = 0.905; Bartlett's sphericity p < 0.001).
  • Stepwise reduction produced a 14-item questionnaire with high internal consistency (Cronbach’s α = 0.920), strong test–retest stability (ICC = 0.924), and good responsiveness (effect size = 0.77).
  • Construct validity was confirmed via significant moderate-to-strong correlations with HADS (r = 0.589, p < 0.001) and SF-12 (r = 0.525, p < 0.001), scoring from 14 to 70 with higher scores indicating worse impairment.

Cite This Study

Reza et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd3726b95aff0620eab15https://doi.org/10.1007/s11136-026-04380-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1P0369 Development and validation of a patient reported outcome measure for rectovaginal fistula; The Vaginal Anal Fistula Quality of Life Scale (VaF-QoL)2026
  2. 2The development of a cryptoglandular anal fistula quality of life scale (AF‐QoL)2024 · 13 citations
  3. 3P0295 PAVFCOMS: An international Delphi consensus study to develop a pouch anal and vaginal fistula core outcome measurement set.2026
  4. 4PAVFCOS : The development of a core outcome set for pouch anal and vaginal fistula2025
  5. 5Development of a new patient-reported outcome measure for complex cryptoglandular fistulas (20-Item complex cryptoglandular fistula questionnaire™): a qualitative study2024 · 1 citations