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Genomic database analysis uncovers extensive functional diversity in extremophile ecosystems, highlighting new opportunities for natural product discovery.
ExMODE (https://db.genomics.cn/exmode/) integrates 3518 samples to build a unified extremophile resource, which hosts 1.35 billion habitat-specific non-redundant genes, 5.25 million representative protein structures, 67,026 metagenome-assembled genomes (MAGs), and 164,132 biosynthetic gene clusters (BGCs). By combining sequence-, structure-, and genome-based exploration across five extreme environments, it enables functional characterization of microbial dark matter through integrated comparative analyses and structure-guided searches. A cross-habitat microviridin case study demonstrates that ExMODE is an effective platform for discovering novel BGCs and biotechnologically valuable natural products.
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Li et al. (2026) studied this question.
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